“Objective: To investigate the influence of cumulative lif

“Objective: To investigate the influence of cumulative lifetime hip joint force on the risk of self-reported medically-diagnosed hip osteoarthritis (OA).

Design: Prospective cohort.


General population.

Participants: Members of Canadian Association of Retired Persons, community-dwelling.

Main outcome: Health-professional diagnosed hip OA, self-reported.

Methods: Exposure data on lifetime physical activity type (occupational, household, sport) and dose (frequency, intensity, duration) was click here collected in 2005. Subjects were ranked in terms of a ‘cumulative peak force index’ (CFPI), a measure of lifetime mechanical hip joint force. Multivariable survival analyses were performed to obtain adjusted effects for mean lifetime CFTRinh172 exposure and during 5-year age periods.

Results: Of 2918 subjects aged 45-85,176(6.03%) developed hip OA during the 2-year follow up (43 men, 133 women). The highest quintile of mean lifetime hip CPFI (HR 2.32; 95% CI 1.31-412), and high hip force in three age periods (35-39, 40-44, 45-49) were independently associated with hip OA. Previous hip injury was an approximate five-fold risk for development of hip OA across all models. In analysis by activity domain (occupation, sport, household), there was a trend (non-significant) for the highest quintile of occupational force, but not sport or household, to be

associated with hip OA.

Conclusions: A newly proposed measure of lifetime mechanical hip force was used to estimate the risk of self-reported, medically-diagnosed hip OA. While there are important limitations, this prospective study suggests that lifelong physical activity is

generally safe. Very high levels of lifetime force from all domains combined, and in particular from occupational forces, may be important in the etiology of hip OA. (C) 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“Millions of patients worldwide who undergo surgical procedures face significant morbidity AZD5153 ic50 and mortality risks. Several systematic reviews have been performed on ancillary treatments aimed at improving surgical outcomes, but their features and scholarly impact are unclear. We describe characteristics of meta-analyses on ancillary treatments aimed at improving surgical outcomes and explore factors associated with scholarly citations.

Systematic reviews published up to 2008 were searched without language restrictions in MEDLINE/PubMed. Reviews focusing on nonsurgical treatments aimed at decreasing mortality or major cardiac complications were included. Associations between content, quality, and bibliometric details and scholarly citations in several indexes were systematically appraised.

From 2,239 citations, 84 systematic reviews were identified.

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