A panel of experts compared the generated documents and the trans

A panel of experts compared the generated documents and the translation was evaluated for 50 undergraduate pharmacy students. The final version was submitted

to a team of experts for content validation. The process of cross-cultural translation and validation result 23 questions in the Portuguese version. Modifications to the grammatical structures were made in order to establish a cross-cultural similarity between the English and Portuguese versions. Regarding the evaluation of the expert panel, seven questions required modifications. In discussion of the consensus panel, all questions were found to be appropriate. This study demonstrated that the Brazilian Portuguese version of the instrument presents a cross-cultural similarity with the original English version.”
“P>The hand-foot-syndrome (HFS, palmoplantar erythrodysesthesia, chemotherapy-associated acral Selleck 3MA erythema) is characterized by painful predominantly palmo-plantar lesions. The association with different chemotherapeutic agents has been known for over 20 years. More recently, HFS has been reported in association with regimens using targeted agents, in particular the multikinase inhibitors (MKI) sorafenib and sunitinib. The HFS associated with MKI has a different distribution and clinical appearance than the traditional disorder. In this review,

similarities and differences between chemotherapy- and MKI-associated HFS are Aurora Kinase inhibitor discussed and current recommendations for their prophylaxis and management are summarized.”
“The composition of the essential oil obtained from the dried flowering aerial parts of Croton polyandrus Spreng. was analyzed by GC and GC-MS. The antimicrobial activity of the essential oil was studied using the

microdilution method and determination of minimal inhibitory concentration (MIC) value. In vitro antiproliferative activity was evaluated in ten human cancer cell lines and two non-tumor cell lines. Total growth inhibition see more (TGI) values were chosen to measure antiproliferative activity. Thirty-three components have been identified in the essential oil of Croton polyandrus Spreng. The major constituents of the essential oil were p-cymene (12.4 %), bornyl acetate (11.0 %) and ascaridole (6.4 %). The results obtained with Croton polyandrus Spreng. oil showed a moderate antifungal activity, with MIC equal the 64 mu g/mL for all fungi strains and weak antibacterial activity; cytocidal effect for most of the strains used were tested only at the highest concentration and showed no cytostatic effect.”
“P>There is no cure for hereditary angioedema (HAE). Therapeutic approaches consist of symptomatic therapy for acute attacks, short-term prophylaxis before surgery, and long-term prophylaxis for those with frequent and severe attacks.

In Germany, C1-INH concentrate and icatibant are licensed for acute therapy. C1-INH concentrate, which is obtained from human plasma, is administered intravenously to restore the deficient C1-INH activity.

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