Conclusion: Lauroyl glucose reduces biofilm growth of all the four test cultures on polystyrene and glass surfaces.

Significance and Impact of the Study: This report is a novel application of the enzymatically synthesized, environmental-friendly nonionic surfactant.”
“There is abundant evidence that

cholesterol metabolism, especially as mediated by the intercellular transporter APOE, is involved in the pathogenesis of sporadic, late-onset Alzheimer disease (SLAD). Identification of other genes involved in SLAD pathogenesis has been hampered since gene association studies, whether individual or genome-wide, experience difficulty in finding appropriate controls in as much as 25% or more of normal adults will develop SLAD. Using 152 centenarians as additional controls this website and 120 “”regular”", 65-75-year-old controls, we show an association of genetic variation in NPC1 with SLAD and/or aging. In this preliminary study, we find gradients of two non-synonymous SNP’s allele frequencies in NPC1 from centenarians through normal controls to SLAD in this non-stratified Polish population. An intervening intronic SNP is not in Hardy-Weinberg equilibria and differs

between centenarians and controls/SLAD. Haplotypes frequencies determined by fast PHASE were somewhat different, and the predicted genotype Selleck Momelotinib frequencies were very different between the three groups. These findings can also be interpreted as indicating a role for NPC1 in aging, a role also suggested by NPC1′s role in Dauer formation (hibernation, a longevity state) in Caenorhabditis elegans. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“Aim: To evaluate the diversity of Vibrio anguillarum isolates from vibriosis-infected Penaeus monodon collected from east coast of India. Methods and Results: Thirty-six V. anguillarum were cultured from specific V. anguillarum medium, further

identified using biochemical tests and confirmed by PCR detection of rpoN Amylase gene. Randomly amplified polymorphic DNA analysis revealed that in each location, the selected V. anguillarum isolates produced a unique band pattern, indicating that the members of this species are genetically heterogeneous. Antibiotic sensitivity results showed that 85%, 72%, 70%, 58%, 45% and 34% of the isolates were resistant to erythromycin, furazolidone, chloramphenicol, oxolinic acid, ciprofloxacin and nitrofurantoin, respectively. Plasmids were found in 70% of the isolates, and nine different plasmid profiles were observed.

Conclusions: Wide ranges of diversity were noted in V. anguillarum isolates collected from P. monodon at different locations of east coast of India.

Significance and Impact of the Study: Molecular typing, antibiotic resistance and plasmid profiles of V.