(C) 2011 European Association for the Study of the Liver Publish

(C) 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.”
“Transporters play a vital role in both the resistance mechanisms of existing drugs and effective targeting of their replacements. Melarsoprol and diamidine compounds similar to pentamidine and furamidine are primarily taken up by trypanosomes of the genus Trypanosoma brucei through the P2 aminopurine transporter. In standardized competition experiments with [(3)H] adenosine, P2 transporter inhibition constants (K(i))

have been determined for a diverse dataset of adenosine analogs, diamidines, Food and Drug Administration-approved compounds and analogs thereof, and custom-designed trypanocidal compounds. Computational biology has been employed to investigate Selleckchem PP2 compound structure diversity in relation to P2 transporter interaction. These explorations have led to models for inhibition predictions of known and novel compounds to obtain information about the molecular basis for P2 transporter inhibition. A common pharmacophore for P2 transporter inhibition has been identified along with other key structural characteristics. Our model provides insight into P2 transporter check details interactions with known compounds and contributes to strategies for the design of novel antiparasitic compounds. This approach offers a quantitative and predictive

tool for molecular recognition by specific transporters without the need for structural or even primary sequence information of the transport Adavosertib supplier protein.”
“Aim: To evaluate the influence of topical iodine-containing antiseptics on neonatal TSH in fullterm infants born by Caesarean section in

an iodine sufficient area.\n\nPopulation and Methods: Urinary iodide excretion (UIE) was estimated in 86 mothers on the second day after delivery by Caesarean section and their 86 full-term neonates. The mothers were divided into two groups according to the use of antiseptic to prepare Cesarean sections: 42 mothers who were prepared with povidone-iodine (Isosept (R), Bosnalijek) comprised the study group, and 47 mothers who were prepared with alcoholic solution (Skinsept (R) color, Ecolab) formed the control group. Neonatal TSH was measured in whole blood drawn between day 3 and 5 of life, spotted on filter paper using a sensitive fluorometric assay (Delfia).\n\nResults: Maternal and neonatal UIE were significantly higher (p <0.05) in the study group compared to the control group. No significant difference was found for neonatal TSH.\n\nConclusion: Our data suggest that perinatal iodine exposure of full-term neonates who were born by Caesarean section in an iodine sufficient area did not influence neonatal TSH, although median UIE was higher, suggesting optimal iodine intake during pregnancy. Further research is needed to define a critical value of urinary iodine concentrations in full-term neonates in an iodine sufficient area that may lead to the impairment of thyroid function.”

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