Exposure to a sample of single-walled nanotubes did not demonstrate the evolution of structural changes, which could be due in part to the higher irradiance levels relative to the damage threshold, employed in the experiment. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3116165]“
“Objective: To determine
minimum alveolar concentration (MAC) of sevoflurane for maintaining bispectral index (BIS) below CA3 cost 50 (MAC(BIS50)) in children.
Background: MAC(BIS50) of sevoflurane in adults was reported to be 0.97%, which has not been elucidated in children.
Methods/Materials: Twenty children, American Society of Anesthesiologists physical status I or II, aged 1-8, were induced and anesthetized with sevoflurane in oxygen. After tracheal intubation, we started maintenance of anesthesia with endtidal sevoflurane concentrations of 2.6%. The endtidal sevoflurane concentration at which BIS was measured was predetermined by the up-down method (with 0.2% as a step size). After 10 min at predetermined endtidal sevoflurane concentrations, BIS was measured for 1 min. MAC(BIS50) was determined using Dixon’s up-down method and probit test.
Result: MAC(BIS50)
of sevoflurane was 2.83% (95% confidence intervals: 2.70-3.14) in children.
Conclusions: MAC(BIS50) of sevoflurane in children was calculated to be three times as high as in adults. This indicates that high endtidal sevoflurane concentration is required to suppress electroencephalogram NVP-BSK805 cell line activity in children.”
“Mitochondrial disorders represent the most common group of inborn errors of metabolism. Clinical manifestations can be extremely variable, ranging from single affected tissues to multisystemic syndromes. Maternally inherited mitochondrial DNA (mtDNA) mutations are a frequent cause, affecting about one in 5000 individuals. The expression of mtDNA mutations differs from nuclear gene defects. Mutations are either homoplasmic or heteroplasmic, and in the latter case disease becomes manifest when the mutation
load exceeds a tissue-specific threshold. Mutation see more load can vary between tissues and in time, and often an exact correlation between mutation load and clinical manifestations is lacking. Because of the possible clinical severity, the lack of treatment and the high recurrence risk of affected offspring for female carriers, couples request prevention of transmission of mtDNA mutations. Previously, choices have been limited due to a segregational bottleneck, which makes the mtDNA mutation load in embryos highly variable and the consequences largely unpredictable. However, recently it was shown that preimplantation genetic diagnosis offers a fair chance of unaffected offspring to carriers of heteroplasmic mtDNA mutations. Technically and ethically challenging possibilities, such maternal spindle transfer and pronuclear transfer, are emerging and providing carriers additional prospects of giving birth to a healthy child.